Journal of hypertension
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Journal of hypertension · Aug 2012
Randomized Controlled Trial Comparative StudySequential nephron blockade versus sequential renin-angiotensin system blockade in resistant hypertension: a prospective, randomized, open blinded endpoint study.
To compare two drug regimens to treat resistant hypertension. ⋯ In patients with resistant hypertension, sequential nephron blockade induces a large and well tolerated reduction in blood pressure via a progressive increase in sodium depletion, and is more effective than sequential renin-angiotensin system blockade.