Journal of hypertension
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Journal of hypertension · Jun 2015
1C.07: PRONEUROTENSIN INDEPENDENTLY PREDICTS CARDIOVASCULAR DISEASE. THE MALMÖ PREVENTIVE PROJECT.
Neurotensin is released from the gut after fat intake and has a role in appetite regulations. Proneurotensin is a stable fragment of the neurotensin precursor hormone and fasting plasma proneurotensin levels have shown to be significantly associated with the development of cardiovascular disease in middle aged participants of the Malmö Diet and Cancer Study. Here, we aimed at replicating the initial findings in an independent second cohort and to extend its validity to an older population. ⋯ Fasting proneurotensin levels are independently associated with the risk of developing cardiovascular disease which replicates the findings in MDC study.
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Journal of hypertension · Jun 2015
2D.03: IMPROVING DIAGNOSTIC STRATEGY IN PATIENTS WITH LONG-STANDING HYPERTENSION, CHEST PAIN AND NORMAL RESTING ECG: VALUE OF THE EXERCISE HIGH-FREQUENCY QRS VERSUS ST-SEGMENT ANALYSIS.
The novel exercise computer-assisted high-frequency QRS-analysis (ex-HF/QRS) has demonstrated improved sensitivity and specificity over the conventional exercise-ST/ECG-segment-analysis (ex-ST/ECG) in the detection of myocardial ischemia. The aim of the present study was to test the implementation in diagnostic value of the ex-HF/QRS in patient with hypertension and chest pain (CP) versus the conventional ex-ST/ECG anlysis alone. ⋯ In patients with long-standing hypertension and CP submitted to risk stratification with exercise tolerance test, the novel ex-HF/QRS shows a valuable incremental diagnostic value over ex-ST/ECG.
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Journal of hypertension · Jun 2015
2D.06: IN HYPERTENSIVE PATIENTS WITH CHEST PAIN AND NORMAL RESTING ECG THE LOW-COST EXERCISE HIGH-FREQUENCY QRS-ANALYSIS IS COMPARABLE TO THE EXERCISE ECHO.
The novel exercise computer-assisted high-frequency QRS-analysis (ex-HF/QRS) has demonstrated improved sensitivity and specificity over the conventional ST/ECG-segment analysis (ex-ST/ECG) in the detection of myocardial ischemia. The aim of the present study was to compare the diagnostic value of the validated exercise-Echocardiography (ex-Echo), needing skilled cardiologist, with the novel low-cost ex-HF/QRS, including the conventional ST-segment analysis. ⋯ In "intermediate-risk" CP patients, the novel ex-HF/QRS was a valuable diagnostic tool in the crowed Emergency Departments. The test might be proposed to avoid additional costly imaging also because it did not require specialized personnel. However, additional study are needed before it can be recommended as a replacement for current techniques.
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Journal of hypertension · Jun 2015
4A.01: LONG-TERM EFFECTS OF RENAL ARTERY DENERVATION IN REAL WORLD PATIENTS WITH UNCONTROLLED HYPERTENSION FROM THE GLOBAL SYMPLICITY REGISTRY.
The Global SYMPLICITY Registry (GSR) provides real world experience regarding the effects of radiofrequency denervation of the renal artery nerves in patients with uncontrolled hypertension. These data in hypertensive patients with a high proportion of concomitant conditions also characterized by sympathetic nervous system will further characterize the effects of renal denervation across a diverse patient population. ⋯ Renal denervation in a large real world population resulted in significant blood pressure reductions 1 year post-procedure. There were no long-term safety concerns following the denervation procedure. These data, including analysis of the BP-lowering effects of RDN in select subgroups, will be updated with two year follow-up of approximately 600 patients in June.
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Journal of hypertension · Jun 2015
4A.10: PREFERENTIAL REDUCTION IN MORNING/NOCTURNAL HYPERTENSION BY RENAL DENERVATION FOR DRUG- RESISTANT HYPERTENSION: A NEW ABPM ANALYSIS OF SYMPLICITY HTN-3 AND HTN-JAPAN.
To study the impact of catheter-based renal artery denervation (RDN) on change in morning and night systolic BP (SBP) defined by ambulatory BP measurements (ABPM) 6 months post-randomization. ⋯ This analysis demonstrated that RDN significantly reduced morning and nighttime SBP compared with control patients suggesting potential benefit of this device approach on cardiovascular protection in drug-resistant hypertension when measurements are captured during higher risk time periods.