Journal of hypertension
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Journal of hypertension · Jun 2015
4D.04: TIMING OF THE CAROTID PRESSURE WAVE INFLECTION POINT IS COUPLED TO SYSTOLIC MYOCARDIAL MOTION IN OLDER PATIENTS WITH CARDIOVASCULAR RISK FACTORS.
Cardiac motion during systole has been shown to be closely associated with carotid pressure wave inflection point timing in young, healthy volunteers. In these individuals the inflection point occurred following the systolic pressure peak (Murgo Type C). The relationship between myocardial motion and the timing of inflection point in older patients with cardiovascular risk factors where the inflection point precedes peak systolic pressure remains unknown. ⋯ : Peak systolic mitral annular motion timing (representing the commencement of myocardial deceleration in systole) always precedes and remains coupled to carotid pressure wave inflection point timing in older patients with established cardiovascular risk factors. This data suggests that the morphology of the central blood pressure waveform may relate more strongly to local ventricular-vascular interactions, rather than wave reflections.
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Journal of hypertension · Jun 2015
5A.01: CORONARY ATHEROSCLEROSIS AND ADVERSE OUTCOME IN HYPERTENSIVE PATIENTS WITH RECENT-ONSET ATRIAL FIBRILLATION AND TROPONIN RISE.
Atrial fibrillation (AF), the most common cardiac-arrhythmia in critical-care, has reached a high prevalence in hypertensive patients. Prevention of systemic-embolism is mandatory; unfortunately, evidence to support the treatment of comorbidities as coronary artery disease (CAD) that contribute to excess mortality is lacking, and the mechanism underlying the troponin-rise during AF without acute coronary syndrome (ACS) is unclear. This study investigates the relationship between CAD, stroke and outcomes in patients with troponin-rise and AF. ⋯ Patients with a recent-onset AF and troponin-rise showed a high prevalence of CVE but not stroke, thus CAD might have a role in poor outcomes.
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Journal of hypertension · Jun 2015
4A.01: LONG-TERM EFFECTS OF RENAL ARTERY DENERVATION IN REAL WORLD PATIENTS WITH UNCONTROLLED HYPERTENSION FROM THE GLOBAL SYMPLICITY REGISTRY.
The Global SYMPLICITY Registry (GSR) provides real world experience regarding the effects of radiofrequency denervation of the renal artery nerves in patients with uncontrolled hypertension. These data in hypertensive patients with a high proportion of concomitant conditions also characterized by sympathetic nervous system will further characterize the effects of renal denervation across a diverse patient population. ⋯ Renal denervation in a large real world population resulted in significant blood pressure reductions 1 year post-procedure. There were no long-term safety concerns following the denervation procedure. These data, including analysis of the BP-lowering effects of RDN in select subgroups, will be updated with two year follow-up of approximately 600 patients in June.
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Journal of hypertension · Jun 2015
Principles of cerebral hemodynamics when intracranial pressure is raised: lessons from the peripheral circulation.
The brain is highly vascular and richly perfused, and dependent on continuous flow for normal function. Although confined within the skull, pressure within the brain is usually less than 15 mmHg, and shows small pulsations related to arterial pulse under normal circumstances. Pulsatile arterial hemodynamics in the brain have been studied before, but are still inadequately understood, especially during changes of intracranial pressure (ICP) after head injury. ⋯ The findings emphasize importance of reducing ICP, when raised, and on the additional benefits of reducing wave reflection from the lower body.
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Journal of hypertension · Jun 2015
1C.01: SOLUBLE UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR AS A PROGNOSTIC MARKER OF ALL-CAUSE AND CARDIOVASCULAR MORTALITY IN A BLACK POPULATION.
Elevated inflammatory markers such as C-reactive protein (CRP) and interleukin-6 (IL-6) are well-known risk factors for cardiovascular mortality. The less familiar marker, soluble urokinase plasminogen activator receptor (suPAR), is known to predict cancer, infections and all-cause mortality. We determined whether suPAR, CRP and IL-6 are predictive of both all-cause and cardiovascular mortality in a black population, highly burdened by cardiovascular disease and HIV infection. ⋯ : SuPAR predicted both all-cause and cardiovascular mortality, independent of traditional risk factors, HIV and other inflammatory markers, underlining the prognostic value of suPAR in a black population.