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Journal of clinical oncology : official journal of the American Society of Clinical Oncology
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Meta Analysis
Efficacy and safety of nonsteroidal antiinflammatory drugs for cancer pain: a meta-analysis.
To assess the efficacy and safety of nonsteroidal antiinflammatory drugs (NSAIDs) in the treatment of cancer pain by meta-analyses of the published randomized control trials (RCTs). ⋯ These findings question whether the traditional World Health Organization (WHO) second analgesic step (addition of a weak opioid when pain is inadequately treated by a nonopioid analgesic alone) is warranted. A lack of comparable studies precluded testing the hypothesis that NSAIDs are particularly effective for malignant bone pain.