Journal of clinical oncology : official journal of the American Society of Clinical Oncology

The most recent articles from: J. Clin. Oncol. May 1997

J. Clin. Oncol. · May 1997

Multicenter Study Clinical Trial

Topotecan, a new active drug in the second-line treatment of small-cell lung cancer: a phase II study in patients with refractory and sensitive disease. The European Organization for Research and Treatment of Cancer Early Clinical Studies Group and New Drug Development Office, and the Lung Cancer Cooperative Group.

To assess activity and toxicity of topotecan in previously treated small-cell lung cancer (SCLC) patients. ⋯ Topotecan has significant activity in SCLC, particularly in patients sensitive to prior chemotherapy, with predictable and manageable toxicity. The incorporation of topotecan in combination chemotherapy regimens for future treatment of SCLC is warranted.

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