Journal of clinical oncology : official journal of the American Society of Clinical Oncology
-
Meta Analysis
Impact of T and N stage and treatment on survival and relapse in adjuvant rectal cancer: a pooled analysis.
To determine survival and relapse rates by T and N stage and treatment method in five randomized phase III North American rectal adjuvant studies. ⋯ Different treatment strategies may be indicated for intermediate-risk versus moderately high- or high-risk patients based on differential survival rates and rates of relapse. Use of trimodality treatment for all patients with intermediate-risk lesions may be excessive, since S plus CT resulted in 5-year OS of approximately 85%; however, 5-year disease-free survival rates with S plus CT were 78% (T1-2/N1) and 69%(T3/N0), indicating room for improvement.