Journal of clinical oncology : official journal of the American Society of Clinical Oncology
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Randomized Controlled Trial
Randomized, placebo-controlled, phase III study of first-line oxaliplatin-based chemotherapy plus PTK787/ZK 222584, an oral vascular endothelial growth factor receptor inhibitor, in patients with metastatic colorectal adenocarcinoma.
PTK787/ZK 222584 (PTK/ZK; vatalanib), an orally active, multitargeted angiogenesis inhibitor, has shown tolerability and promising activity in early-phase studies, which led to a phase III trial in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4). ⋯ Although the efficacy objectives of this study were not met, a subgroup of patients who may potentially benefit from small-molecule vascular endothelial growth factor receptor inhibitor therapy has been identified and further research is warranted.
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We previously described a novel breast cancer staging system for assessing prognosis after neoadjuvant chemotherapy on the basis of pretreatment clinical stage (CS), estrogen receptor status (E), grade (G), and post-treatment pathologic stage (PS). This clinical-pathologic stage (CPS) + EG staging system assigned and summed points for each factor, allowing for better determination of breast cancer-specific survival than CS or PS alone. The current study was undertaken to validate this staging system using internal and external cohorts. ⋯ The current study validates the CPS + EG staging system in two independent cohorts. We recommend that biologic markers and response to treatment be incorporated into revised versions of the AJCC staging system for patients receiving neoadjuvant chemotherapy.
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1097 Background: Breast cancer (BC) is the second most common cause of brain metastases (BM). Various prognostic indexes such as RPA to predict survival in BM patients have been developed in patients enrolled in RTOG trials. ⋯ BC specific graded prognostic assessment (GPA) has been developed (Sperduto et al., IJROBP. 2010) and modified (ASCO 2010 abst. #1028) to reflect unique biologic feature of BC. The purpose of this study is to appraise and refine the Sperduto's BC-specific GPA index (S' GPA).