Journal of comparative psychology
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Intravenous administration of 2-deoxy-D-glucose (2-DG), a competitive inhibitor of glucose utilization, increased the food intake of rats. Infusions of glucose or mannose abolished this effect, whereas equimolar fructose solutions did not affect 2-DG-induced feeding. ⋯ This site is likely to be in the brain, not the liver, because all three sugars can nourish peripheral tissue but only fructose cannot penetrate the blood-brain barrier. Moreover, 2-DG-induced feeding was abolished by intravenous infusion of beta-hydroxybutyrate, a substrate that can be oxidized by brain and other tissues but not by the liver.