The American journal of emergency medicine
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Letter Case Reports
Recurrent central venous malposition caused by severe lower airway distortion.
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Review Case Reports
Anaphylactic shock associated with intravenous thrombolytics: case report and an analysis from adverse event reporting system.
Adverse events including intracerebral hemorrhage and reperfusion arrhythmias are well known to occur with thrombolytic therapy. We report a case report of anaphylactic reaction directly attributable to intravenous (IV) recombinant tissue plasminogen activator and identify additional cases through review of the Food and Drug Administration Adverse Event Reporting System. A systematic review of Adverse Event Reporting System was performed for allergic adverse events occurring in conjunction with IV thrombolytics. ⋯ There was 1 death directly attributable to allergic reaction in a patient who received IV reteplase for MI. Although IV alteplase is identical to endogenous tissue plasminogen activator, it appears to be the most common cause of allergic reaction among currently used thrombolytics, with or without concomitant administration of angiotensin-converting enzyme inhibitors. A greater awareness among physicians may result in prompt recognition and treatment.