The American journal of emergency medicine
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Randomized Controlled Trial
Topical ethyl chloride to reduce pain associated with venous catheterization: a randomized crossover trial.
To compare pain associated with venous catheterization after administration of topical ethyl chloride vs placebo among emergency department health care providers. ⋯ We found that topical ethyl chloride yields a greater reduction in pain associated with venous catheterization compared with topical placebo.
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Randomized Controlled Trial
Prospective, randomized, double-blind controlled trial comparing vapocoolant spray vs placebo spray in adults undergoing venipuncture.
Topical anesthetics are used to decrease procedural pain such as venipuncture. Advantages of vapocoolants include rapid onset, ease of application, low cost, and lack of associated pain of injection and other needlestick-related risks. We hypothesized that the pain of venipuncture would be reduced by at least 1.8 points on a 10-point numerical rating scale after application of a vapocoolant compared with placebo. ⋯ The vapocoolant significantly decreased venipuncture pain in adults compared with placebo and was well tolerated with minor adverse effects that resolved quickly. There were no significant differences in VS and no visible skin changes documented at the site by photographs taken within 5 to 10 minutes postspray/venipuncture.
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NLRP3 inflammasome activation is recently reported to be linked to the pathogenesis of sepsis. Artemisinin is shown to play beneficial effects in sepsis. However, the impacts of artemisinin on burn sepsis have not been investigated. This study is designed to investigate the role of artemisinin in burn sepsis and the involvement of NLRP3 inflammasome activation. ⋯ Artemisinin protects mice from burn sepsis by attenuating the inflammatory response and alleviating inflammatory infiltration in vital organs, likely through inhibiting the activation of NLRP3 inflammasome.
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Letter Randomized Controlled Trial Comparative Study
Comparison of two chest compression techniques when using CBRN-PPE: a randomized crossover manikin trial.
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Observational Study
Effect of predischarge blood pressure on follow-up outcomes in patients with severe hypertension in the ED.
Although emergency department (ED) patients with asymptomatic severe hypertension (ASH) generally have no serious short-term hypertension-related adverse events, it is unclear whether persistently high discharge blood pressure (BP) affects the outcome due to the dynamic nature of BP. ⋯ Predischarge BP value is not associated with immediate serious adverse events and does not affect short-term BP control in ED patients with ASH. Further study on the need to lower BP during the ED stay and on antihypertensive prescriptions for these patients is required.