The American journal of emergency medicine
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The depressed heart function is the main complication to cause death of septic patients in clinic. It is urgent to find effective interventions for this intractable disease. In this study, we investigated whether butyrate could be protective for heart against sepsis and the underlying mechanism. ⋯ In conclusion, pretreatment with butyrate attenuated septic heart depression via anti-inflammation and anti-oxidation.