Alcohol and alcoholism : international journal of the Medical Council on Alcoholism
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Randomized Controlled Trial
Efficacy and safety of pregabalin in the treatment of alcohol withdrawal syndrome: a randomized placebo-controlled trial.
The objective of this study was to collect preliminary data on the efficacy and safety of pregabalin in attenuating the severity of alcohol withdrawal symptoms during detoxification treatment in alcohol dependence. ⋯ The study demonstrates the relative safety of pregabalin in the treatment of AWS. However, the results do not provide evidence in favor of pregabalin compared with placebo concerning its efficacy in the treatment of AWS.
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Randomized Controlled Trial
Alcohol withdrawal syndrome: symptom-triggered versus fixed-schedule treatment in an outpatient setting.
To investigate whether, in the treatment with chlordiazepoxide for outpatient alcohol withdrawal, there are advantages of symptom-triggered self-medication over a fixed-schedule regimen. ⋯ Symptom-triggered self-medication was as safe as fixed-schedule medication in treating outpatients with AD and mild to moderate symptoms of AWS. The SAWS is a powerful monitoring tool, because it is brief and permits the subject to log the withdrawal symptoms.
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Randomized Controlled Trial Multicenter Study
Treatment of alcoholic polyneuropathy with vitamin B complex: a randomised controlled trial.
To evaluate the therapeutic efficacy and safety of BEFACT Forte 'new formulation' and BEFACT Forte 'old formulation' in the treatment of sensory symptoms of alcoholic polyneuropathy. ⋯ A specific vitamin B complex (with and without folic acid) significantly improved symptoms of alcoholic polyneuropathy over a 12-week treatment period.
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Randomized Controlled Trial
Telephone screening for hazardous drinking among injured patients seen in acute care clinics: feasibility study.
We evaluated the effectiveness of telephoning injured patients after discharge, compared with contacting them in the clinic during the acute care visit, for screening for hazardous drinking and eliciting willingness to participate in a lifestyle intervention trial. ⋯ Telephone screening is a feasible and efficient method for screening moderately injured adult patients for hazardous drinking, but characteristics of the clinical site (including personnel) influence its effectiveness. Trauma and acute care clinics are likely to be fruitful sites for identification of patients with hazardous drinking, whether for enrollment into brief intervention trials or treatment programmes.
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Randomized Controlled Trial Comparative Study Clinical Trial
Two-year outcome of coping skills training, group support and information for spouses of alcoholics: a randomized controlled trial.
To evaluate three different intervention programmes for spouses of alcoholics. ⋯ A post hoc examination of subjects with SCL-90 scores above general population means, showed less improvement in the Information group than the two therapy groups combined (P < 0.05).