Alcohol and alcoholism : international journal of the Medical Council on Alcoholism
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Review Meta Analysis
Long-Term Alcohol Consumption and Breast, Upper Aero-Digestive Tract and Colorectal Cancer Risk: A Systematic Review and Meta-Analysis.
Cancers of female breast, upper aero-digestive tract (UADT) (oral cavity, pharynx, larynx, oesophagus) and colorectum are causally related to alcohol consumption. Although alcohol consumption is likely to vary during life, the few studies that have explicitly measured lifetime consumption or intake over time have not been summarised. We therefore conducted a systematic review and meta-analysis. ⋯ Our findings confirm dose-dependent associations between long-term alcohol intake and breast, UADT and colorectal cancer.
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Meta Analysis Comparative Study
A critical review of pharmacoeconomic studies of acamprosate.
This review assessed the published data on the cost-effectiveness of acamprosate for the treatment of alcohol dependence. ⋯ All five studies have produced consistent results, showing the use of acamprosate, which enhances abstinence rates, to reduce the total costs of treatment and thus be dominant over other rehabilitation strategies not involving pharmacotherapy. In all of the studies, the principal cost-driver is hospitalization. Although there is a short-term increase in treatment costs associated with drug acquisition, these are recovered from long-term savings attributable to reduced hospitalization and rehabilitation costs.