Der Orthopäde
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Randomized Controlled Trial
Vitamin E-blended versus conventional polyethylene liners in prostheses : Prospective, randomized trial with 3-year follow-up.
Despite continuous technical improvements, polyethylene wear debris induced periprosthetic osteolysis remains the main cause for failure of hip arthroplasty. Progressive oxidation of polyethylene was identified as another risk factor for material failure. To overcome this problem, antioxidants such as vitamin E (alpha-tocopherol) were supplemented by diffusion into the latest generation of polyethylene liners. ⋯ The present study demonstrates that the supplementation of vitamin E to polyethylene liners is reliable and safe without showing higher complication rates compared with conventional polyethylene liners. The shortterm clinical outcome of vitamin E-blended (UHMWPE‑XE) is equivalent to those of conventional highly cross-linked polyethylene liners.
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Randomized Controlled Trial
Intra-articular injections of platelet-rich plasma, hyaluronic acid or corticosteroids for knee osteoarthritis : A prospective randomized controlled study.
Knee osteoarthritis (KOA) is a degenerative joint disease leading to pain and disability for which no curative treatment exists. Intra-articular (IA) therapies are part of this multimodal approach and are approved by the Food and Drug Administration (FDA) and European Medicines Agency (EMA). Platelet-rich plasma (PRP), hyaluronic acid (HA), and corticosteroids (CS) have been increasingly used in recent years to treat KOA. ⋯ Intra-articular PRP injections into the knee for symptomatic early stages of KOA are a valid treatment option. The clinical efficacy of IA-PRP is comparable to that of the IA-HA and IA-CS forms after 3 months and the long-term efficacy of IA PRP is superior to IA-HA and IA-CS.
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Randomized Controlled Trial Comparative Study
[Chronic low back pain : Comparison of mobilization and core stability exercises].
For the treatment of chronic low back pain (cLBP), both core stability and mobilization exercises were introduced. The aim of this prospective randomized clinical pilot study was to compare the efficacy of mobilization and core stability exercises with regard to objective and subjective outcome measures in patients with cLBP. ⋯ With regard to their daily complaints, patients with cLBP can be treated using standardized mobilization exercises in addition to core stability exercises.
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Randomized Controlled Trial
[Postoperative analgesia after total knee arthroplasty: Continuous intra-articular catheter vs. continuous femoral nerve block].
Postoperative pain management after total knee arthroplasty (TKA) remains a great challenge even today. In the context of new fast-track concepts, the importance of multimodal therapies for the effective treatment of pain and the reduction of side effects, as well as for the rapid ambulation of patients is increasing. Therefore, new continuous intra-articular catheter-systems (IAC) are under investigation. ⋯ The perioperative treatment with an IAC system is an easy technique, which ensures a markedly faster ambulation following TKA compared to the treatment with continuous FNB. Hence, its usage, especially in fast-track concepts can be recommended. In this study, a comparison of pain intensity, the additional requirement of opioids and early range of motion (ROM) offers no benefits compared to FNB. Due to time savings cost reduction can be achieved.
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Randomized Controlled Trial
[Mild whole body hyperthermia in combination with inpatient multimodal oriented pain therapy: evaluation in patients with chronic unspecific lumbar back pain].
A randomized controlled clinical trial was implemented to evaluate the effectiveness of combined mild hyperthermia therapy (body core temperature 38.4 °C) and multimodal inpatient rehabilitation for patients suffering from chronic low back pain when compared to multimodal pain therapy alone. ⋯ When combined with a multimodal inpatient lower back pain functional therapy in patients showing morphological degeneration, the mild hyperthermia therapy demonstrated statistically significant, although not clinically relevant benefits in comparison to the multimodal treatment alone. However, regarding the moderate overall patient-related benefits as measured in terms of the Oswestry disability index, the benefit of the underlying multimodal therapy concept implementation must be critically discussed irrespective of its combination with mild hyperthermia therapy.