Resuscitation
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Randomized Controlled Trial Multicenter Study
Predictive value of interleukin-6 in post-cardiac arrest patients treated with targeted temperature management at 33°C or 36°C.
Post-cardiac arrest syndrome (PCAS) is characterized by systemic inflammation, however data on the prognostic value of inflammatory markers is sparse. We sought to investigate the importance of systemic inflammation, assessed by interleukin-6 (IL-6) in comatose survivors of out-of-hospital cardiac arrest. ⋯ In patients surviving >24h following cardiac arrest, IL-6 levels were significantly elevated and associated with severity of PCAS with no significant influence of target temperature. High IL-6 levels were associated with increased mortality. Measuring levels of IL-6 did not provide incremental prognostic value.
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Multicenter Study Observational Study
Changes in coagulation during therapeutic hypothermia in cardiac arrest patients.
Therapeutic hypothermia improves neurological outcome in patients resuscitated after out-of-hospital cardiac arrest. The aim was to investigate whether therapeutic hypothermia induced impaired coagulation. ⋯ NCT02179021.