Upsala journal of medical sciences
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Randomized Controlled Trial
Effect of dexmedetomidine on plasma brain-derived neurotrophic factor: A double-blind, randomized and placebo-controlled study.
Dexmedetomidine (DEX) has neuro-protective effects, but the clinical mechanism remains unclear. ⋯ It appears that DEX could reverse the reduced plasma concentrations of BDNF caused by anesthetics, and this effect lasted for 24 hours after surgery.
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Randomized Controlled Trial
Twelve-month follow-up of advance provision of emergency contraception among teenage girls in Sweden-a randomized controlled trial.
The objective of this study was to evaluate the effect of an intervention with advance provision of emergency contraceptive pills (ECP), condoms, and extended information to a targeted group of teenage girls, compared with a control group, 12 months after intervention. ⋯ Even up to 12 months following the intervention, advance provision of ECP at one single occasion, to a specific target group of adolescent girls, shortens the time interval from unprotected intercourse to pill intake, without jeopardizing contraceptive use or increasing sexual risk-taking. Considering the clinical relevance of these results, we suggest that advance provision of ECP could be implemented as a routine preventive measure for this target group.