Upsala journal of medical sciences
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Randomized Controlled Trial
Effects of spironolactone on extrasystoles and heart rate variability in haemodialysis patients: a randomised crossover trial.
Spironolactone treatment reduces mortality in haemodialysis (HD) patients. The objective of this study was to evaluate if spironolactone affects cardiac electric activity in this population. ⋯ Spironolactone treatment increases PVCs in HD, indicating a possible proarrhythmic effect. However, improved cardiac autonomic function, as indicated by an increased HRV, may contribute to the survival benefit from spironolactone treatment in HD patients.