European journal of anaesthesiology
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Randomized Controlled Trial Comparative Study
Comparison of the relative analgesic efficacies of epidural or intramuscular diamorphine following total knee arthroplasty.
Debate has proliferated as to the true site of action of opioids when placed in the epidural space. The aim of this study was to compare the analgesic effects of a bolus of diamorphine given by the epidural or intramuscular route. ⋯ This study has shown the superior analgesic efficacy of epidural diamorphine when compared to intramuscular injection.
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Randomized Controlled Trial
Use of a target-controlled infusion system for propofol does not improve subjective assessment of anaesthetic depth by inexperienced anaesthesiologists.
Target-controlled infusion, via the calculated effect compartment concentrations, may help anaesthesiologists to titrate anaesthetic depth and to shorten recovery from anaesthesia. ⋯ A target-controlled infusion system does not help inexperienced anaesthesiologists to assess anaesthetic depth or to shorten recovery times, but may reduce episodes of overly light anaesthesia and thus help to prevent awareness.