European journal of anaesthesiology
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A new minimally invasive metabolic test for the diagnosis of susceptibility for malignant hyperthermia measuring intramuscular p(CO(2)) and lactate following local application of caffeine and halothane in humans was recently proposed. The present study tested the hypothesis that a more simplified test protocol allows a differentiation between malignant hyperthermia susceptible (MHS) and malignant hyperthermia nonsusceptible (MHN) and control individuals. ⋯ Local caffeine and halothane injection increased intramuscular metabolism in MHS individuals significantly more than in the two other groups. In contrast to previous investigations, direct injection of the concentrations of halothane described here increased lactate and p(CO(2)) even in MHN skeletal muscle.
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Randomized Controlled Trial
Effects of perioperative intravenous low dose of ketamine on postoperative analgesia in children.
Low dose of ketamine reduces postoperative pain and opioid consumption in adult studies. However, there are only a few data with controversial results in the paediatric population. The aim of this randomized controlled trial was to evaluate the use of low doses of intravenous ketamine on postoperative pain in children after surgery on the lower part of the body. ⋯ The study failed to show any evidence of benefit of ketamine to improve analgesia in children when given in addition to a multimodal analgesic therapy with paracetamol, a NSAID and an opiate.
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Randomized Controlled Trial
Learning fibreoptic intubation with a virtual computer program transfers to 'hands on' improvement.
Fibreoptic intubation is an essential skill in anaesthesiology that is challenging to learn in the clinical setting. The goal of this study was to evaluate 'virtual fibreoptic intubation' (VFI) software as an adjunct to the traditional fibreoptic intubation teaching. ⋯ Self-training in fibreoptic intubation with the VFI software may improve the acquisition of fibreoptic intubation skills.
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Randomized Controlled Trial Comparative Study
Management of the predicted difficult airway: a comparison of conventional blade laryngoscopy with video-assisted blade laryngoscopy and the GlideScope.
We investigated whether the use of two different video laryngoscopes [direct-coupled interface (DCI) video laryngoscope and GlideScope] may improve laryngoscopic view and intubation success compared with the conventional direct Macintosh laryngoscope (direct laryngoscopy) in patients with a predicted difficult airway. ⋯ We conclude that the video laryngoscope and GlideScope in particular may be useful instruments in the management of the predicted difficult airway.