European journal of anaesthesiology
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Review Meta Analysis
Preoperative celecoxib in noncardiac surgery: A systematic review and meta-analysis of randomised controlled trials.
Postoperative pain continues to be undertreated after noncardiac surgery. Preoperative analgesic administration may enhance postoperative analgesia. ⋯ Results of this study are limited by significant heterogeneity and inclusion of mainly small trials. However, there appears to be a slight to modest benefit of preoperative celecoxib on reducing postoperative morphine consumption, pain, nausea and vomiting.