European journal of anaesthesiology
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Randomized Controlled Trial Multicenter Study Comparative Study Observational Study
Aprotinin vs. tranexamic acid in isolated coronary artery bypass surgery: A large multicentre observational study.
Aprotinin appears to be more efficacious than lysine analogues to reduce bleeding and transfusion of blood products in high-transfusion-risk cardiac surgical patients. However, in isolated coronary artery bypass graft (CABG) surgery, the results from head-to-head trials remain less conclusive. ⋯ In patients undergoing isolated CABG, aprotinin was more effective than TXA in reducing postoperative blood loss, and no safety concerns were identified. The benefits of aprotinin should be considered when evaluating the risk of major blood loss and transfusion in patients scheduled for isolated CABG surgery.