European journal of anaesthesiology
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Multicenter Study Observational Study
A serotonin transporter polymorphism is associated with postoperative nausea and vomiting: An observational study in two different patient cohorts.
Clinical risk factors for postoperative nausea and vomiting (PONV) are well described, whereas genetic findings are conflicting. ⋯ In two independent cohorts, in addition to the well known clinical factors, a polymorphism of 5-HTTLPR in the serotonin transporter was independently associated with PONV. A possible evaluation of this biomarker to improve risk prediction within the scope of precision medicine should be considered.