Anaesthesia and intensive care
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Anaesth Intensive Care · Mar 2013
ReviewIs suppression of apoptosis a new therapeutic target in sepsis?
Sepsis remains as a leading cause of death in critically ill patients. Unfortunately, there have been very few successful specific therapeutic agents that can significantly reduce the attributable mortality and morbidity of sepsis. ⋯ In this review article, we summarise the critical role of apoptosis of the immune cells in the pathophysiology of sepsis and propose that blocking cell-signaling pathways leading to apoptosis may present a promising specific therapy for sepsis. Various methods to inhibit apoptosis including the cell surface Fas receptor pathway inhibitors, caspase inhibitors, over-expression of anti-apoptotic genes and small interfering ribonucleic acid therapy are discussed.
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Anaesth Intensive Care · Mar 2013
Randomized Controlled TrialSevoflurane alone and propofol with or without remifentanil for electroconvulsive therapy-a randomised, crossover study.
We compared the effectiveness of three anaesthetic regimens (propofol alone, propofol with remifentanil and sevoflurane alone), with respect to seizure duration and seizure quality in patients undergoing electroconvulsive therapy. Thirty-nine patients underwent a total of 234 electroconvulsive therapy treatments in this prospective, observer blinded, crossover study. Each patient received either propofol 1 mg/kg alone (Group P), propofol 0.5 mg/kg and remifentanil 1 µg/kg (Group R), or sevoflurane alone 6% (Group S) for their initial electroconvulsive therapy session. ⋯ The mean motor and electroencephalogram seizure durations were significantly longer in Groups P and R compared to Group S (P <0.001). The postictal suppression index and early and midictal amplitude values were not significantly different among the groups. These findings indicate that the three anaesthetic regimens had similar effects on seizure quality parameters, although sevoflurane was associated with shorter seizure durations than propofol or propofol-remifentanil.
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There is widespread variation as to the method of presentation of informed anaesthetic consent with little empirical data on the nature of communication and how much information is retained. At a dedicated anaesthesia pre-admission clinic, 149 patients undergoing elective surgery under general anaesthesia were both verbally informed and shown written information about four major and three minor anaesthesia risks. The major risks were death, pneumonia, heart attack and stroke. ⋯ On the day of scheduled surgery, retention of information about these anaesthetic risks was examined. Thirty-eight patients (26%) could not recall any anaesthesia risks, 55 patients (37%) could not recall any major risks and 126 patients (84%) could not recall any minor risks. Our findings indicate that patients should receive a second explanation on the day of surgery, even if informed consent was provided only two weeks earlier.
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Anaesth Intensive Care · Mar 2013
Simulation training for rare medications in the intensive care unit-a study with bivalirudin.
The purpose of this study was to assess whether simulation training can improve the clinician's ability to predict the effect of bivalirudin infusion. Six clinicians with experience using bivalirudin and six without experience (Groups Exp and NoExp) entered predictions for partial thromboplastin time while viewing a running display of clinical data obtained retrospectively from intensive care unit patients who had received bivalirudin infusion after cardiac surgery. All clinicians entered guesses for the same sequence of 30 patients. ⋯ The guessing-errors of Group NoExp were significantly higher than Group Exp in the first and second terciles, with no significant difference in the third tercile. Linear regression indicated a significantly steeper learning curve in Group NoExp than Exp. Brief simulation training using retrospective patient data improved the ability of inexperienced clinicians to predict the effect of bivalirudin as compared to experienced clinicians.
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Anaesth Intensive Care · Mar 2013
Case ReportsDifferentiating athlete's heart from inherited cardiac pathology: the challenge of repolarisation abnormalities presenting during anaesthesia.
This case report describes an asymptomatic healthy male professional athlete who underwent general anaesthesia for a routine orthopaedic operation. Peri-procedure, pronounced ST elevation suggestive of myocardial ischaemia manifested on the electrocardiogram lasting for four hours post-procedure, upon which the athlete developed deep and diffuse inferolateral T-wave inversion. These changes resolved spontaneously and the patient remained clinically stable throughout. This case demonstrates the clinical conundrum facing anaesthetists attempting to differentiate between repolarisation anomalies that are commonly observed in high-level athletes and those of inherited cardiac pathology, namely hypertrophic cardiomyopathy, which is the leading cause of sudden cardiac death in young athletes.