The Clinical journal of pain
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The objective of this study was to investigate the hypothalamic-pituitary-gonadal response to intrathecal opioids. ⋯ Hypogonadotrophic hypogonadism is a common complication of intrathecal opioid therapy in both men and women.
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Randomized Controlled Trial Clinical Trial
Use of virtual reality for adjunctive treatment of adult burn pain during physical therapy: a controlled study.
The pain experienced by burn patients during physical therapy range of motion exercises can be extreme and can discourage patients from complying with their physical therapy. We explored the novel use of immersive virtual reality (VR) to distract patients from pain during physical therapy. ⋯ Results provided preliminary evidence that VR can function as a strong nonpharmacologic pain reduction technique for adult burn patients during physical therapy and potentially for other painful procedures or pain populations.
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Randomized Controlled Trial Clinical Trial
Effect of acupuncture upon experimentally induced ischemic pain: a sham-controlled single-blind study.
To investigate the hypoalgesic effect of true and sham acupuncture upon experimentally induced ischemic pain. ⋯ The results of the study provide no convincing evidence for a superior hypoalgesic effect of acupuncture compared with "sham" procedures on this model of experimental pain.
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Clinical Trial
Topical lidocaine patch relieves a variety of neuropathic pain conditions: an open-label study.
Our goal was to perform a pilot study to assess the effectiveness and tolerability of a topical lidocaine patch (Lidoderm) for the treatment of peripheral neuropathic pain conditions other than postherpetic neuralgia. ⋯ The Lidoderm patch provided clinically meaningful pain relief in most of these refractory neuropathic pain patients without side effects. Controlled trials need to be performed to confirm these preliminary findings.
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In almost every neuropathic pain state caused by peripheral nerve damage, whether due to trauma or disease, both structural damage and an inflammatory response exist. ⋯ These data suggest the possibility of an important interaction between the immune system and the nervous system in neuropathic pain and suggest that drugs modulating the immune system may be useful therapies in at least some neuropathic pain states.