The Clinical journal of pain
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Randomized Controlled Trial
Alternating-frequency TENS effects on experimental pain in healthy human participants: a randomized placebo-controlled trial.
Transcutaneous electrical nerve stimulation (TENS) is a modality commonly used in pain management. ⋯ The alternating-frequency setting does not result in large hypoalgesic effects such as those previously reported using fixed-frequency TENS.
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Randomized Controlled Trial
Somatosensory sensitivity in patients with persistent idiopathic orofacial pain is associated with pain relief from hypnosis and relaxation.
In a recent study hypnosis has been found to relieve persistent idiopathic orofacial pain. Quantitative sensory testing (QST) is widely used to evaluate somatosensory sensitivity, which has been suggested as a possible predictor of management outcome. The objectives of this study were to examine: (1) possible associations between clinical pain relief and baseline somatosensory sensitivity and (2) the effect of hypnosis management on QST parameters. ⋯ High pain sensitivity at baseline may predict poor pain management outcome. In addition, despite clear clinical pain relief, hypnosis did not significantly or specifically influence somatosensory sensitivity. Future studies should further explore QST measures as possible predictors of different management response in orofacial pain conditions.
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Randomized Controlled Trial
Evaluation of multiday analgesia with etoricoxib in a double-blind, randomized controlled trial using the postoperative third-molar extraction dental pain model.
To evaluate the analgesic effects of etoricoxib and comparator agents on the second and third days after oral surgery. ⋯ Pain control was most favorable for the etoricoxib doses and ibuprofen. Global Assessments of Study Medication continued to differentiate the treatments and demonstrated greater efficacy for etoricoxib on Days 2 and 3 compared with placebo and A/C (NCT00694369).