The Clinical journal of pain
-
Review Meta Analysis
Effects of Combining Dexmedetomidine and Opioids for Postoperative Intravenous Patient-controlled Analgesia: A Systematic Review and Meta-analysis.
This meta-analysis evaluated the effects of opioid-dexmedetomidine (DEX) combinations for postoperative patient-controlled analgesia (PCA). ⋯ These data suggest that an opioid-DEX combination is a safe and effective strategy for postoperative intravenous PCA.
-
The prevalence of knee osteoarthritis (OA) is increasing with the aging population and is exacerbated by the growing numbers of obese older adults. Low levels of vitamin D, measured by serum 25-hydroxyvitamin D (25(OH)D), in older adults and obese individuals are correlated with several negative health conditions, including chronic pain. This cross-sectional study sought to examine the interactive influence of 25(OH)D levels and obesity on knee OA pain and functional performance measures. ⋯ The mechanisms by which adequate 25(OH)D levels are associated with pain severity and improved function have not been completely elucidated. It may be that the pleiotropic role of biologically active 25(OH)D influences pain and pain processing through peripheral and central mechanisms. Alternatively, higher levels of pain may lead to reduced outdoor activity, which may contribute to both obesity and decreased vitamin D. Thus, investigating vitamin D status in obese and nonobese individuals with knee OA warrants further study.
-
To prospectively describe the prevalence and predictive factors of chronic postsurgical pain (CPSP) and poor global recovery in a large outpatient population at a university hospital, 1 year after outpatient surgery. ⋯ Moderate to severe CPSP after outpatient surgery is common, and should not be underestimated. Patients at risk for developing CPSP can be identified during the preoperative phase.
-
To characterize the incidence, severity, quality, and treatment of pain in a large cohort of Marfan patients. ⋯ Our findings suggest that pain symptoms in Marfan patients are underestimated and likely undertreated. We propose a need for improved patient and medical provider awareness of pain management options in this population, including the development of effective algorithms to treat pain in Marfan patients.
-
To test the hypothesized associations between measures of the behavioral inhibition system (BIS) and behavioral activation system (BAS) and both the intensity and frequency of pain. ⋯ The findings are consistent with predictions based on a model hypothesizing that pain has a nonlinear impact on both BIS and BAS, with a stronger impact on BIS than BAS. If the current results are replicated in other samples, including samples of individuals with chronic pain, they have important implications for identifying biological factors that could influence pain and behavioral responses to pain, as well as for the development and evaluation of treatments that could enhance positive treatment outcomes.