The Clinical journal of pain
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Randomized Controlled Trial
Duloxetine as an Analgesic Reduces Opioid Consumption after Spine Surgery: A Randomized, Double-blind, Controlled Study.
Multimodal analgesia is widely advocated for the control of perioperative pain in an effort to reduce the use of opioid. Duloxetine is a selective inhibitor of serotonin and norepinephrine reuptake with efficacy for chronic pain conditions. The primary objective of this study was to evaluate the efficacy of two 60 mg oral doses of duloxetine in terms of fentanyl consumption during the postoperative period in patients undergoing elective spine surgery. ⋯ Duloxetine was effective as an adjunct for postoperative analgesia and reduced opioid consumption.
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Randomized Controlled Trial
Treatment Adherence in Child and Adolescent Chronic Migraine Patients: Results from the Cognitive Behavioral Therapy and Amitriptyline Trial.
To examine treatment adherence among children and adolescents with chronic migraine who volunteered to be in a clinical trial using 3 measures: treatment session attendance, therapy homework completion, and preventive medication use by daily diary. ⋯ Our findings demonstrate that youth with chronic migraine who agree to be a part of a clinical trial do quite well at attending therapy sessions, and report that they are adherent to completing home/practice between sessions and taking medication. These results lend further support to consideration of CBT+A as a first-line treatment for youth with chronic migraine and suggest that measurement of adherence when this treatment is provided in practice will be important.