The Clinical journal of pain
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In the context of the current opioid epidemic, there has been a renewed interest in the use of ketamine as an analgesic agent. ⋯ In this review, we examined basic mechanisms of ketamine and its current clinical use and potential novel use in pain management.
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This review aimed to explore the processes that underlie the main and the buffering effect of social support on decreased pain experience. ⋯ This review presents evidence that the stress-buffering effect is more often able to account for the relationship between social support and pain experience. Moreover, findings suggest the critical significance of stress appraisal and attenuated stress systems in linking social support to aspects of reduced pain experience. Findings implicate the role of integrating perceived support and intimacy in support-oriented interventional trials for chronic pain.
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Review Meta Analysis Comparative Study
Comparison of the Efficacy of Different Analgesia Treatments for Total Knee Arthroplasty: A Network Meta-Analysis.
The severe pain after total knee arthroplasty (TKA) brings many patients more suffering, longer hospital stay, and higher expenses. This study was designed to assess the relative efficacy of several clinical treatments for postoperative analgesia of TKA through network meta-analysis based on multiple published randomized controlled trials. ⋯ Considering both pain score and morphine consumption, cFNB was potentially the most efficacious postoperative treatment for patients undergoing TKA.
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To evaluate the difference between combination pharmacotherapy and monotherapy on low back pain (LBP). ⋯ Combination pharmacotherapy is more effective than placebo or monotherapy in the management of pain and disability in chronic LBP, but not in acute LBP. Further, combination pharmacotherapy has a higher risk of adverse effects than placebo and monotherapy.