The Clinical journal of pain
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Meta Analysis
Efficacy and Safety of Low-dose Codeine Containing Combination Analgesics for Pain: Systematic Review and Meta-analysis.
To investigate the efficacy and safety of combination analgesic products containing low-dose codeine (up to 30 mg/dose) for pain. ⋯ There is low to moderate level evidence that combination analgesic products containing low-dose codeine provide small to moderate pain relief for acute and chronic pain conditions in the immediate short term with limited trial data on use beyond 24 hours. Further research examining regular use of these medicines is needed with more emphasis on measuring potential harmful effects.