The Clinical journal of pain
-
Randomized Controlled Trial
Evaluation of the Efficacy of Prolonged Pregabalin Administration before and after Surgery in Patients Undergoing Arthroscopic Anterior Cruciate Ligament Repair: A Prospective, Randomized, Double-Blind Study.
Reconstruction of the knee ligament causes postoperative pain and delayed rehabilitation. ⋯ A prolonged preoperative and postoperative pregabalin prescription for anterior cruciate ligament repair decreased the need for supplementary analgesics during the first 24 postoperative hours but increased dizziness.
-
Randomized Controlled Trial
A Randomized Controlled Comparison of Epidural Analgesia Onset Time and Adverse Reactions During Labor with Different dose Combinations of Bupivacaine and Sufentanil.
The purpose was to compare the effects of 3 different dose combinations of bupivacaine and sufentanil on the onset of analgesia and the occurrence of side effects. ⋯ The B125S5 combination may be superior to the B1S5 and B1S10 combinations as an initial dose for epidural analgesia to achieve rapid effective analgesia with minimal side effects.
-
Randomized Controlled Trial
Dexmedetomidine 2▒ppm is Appropriate for the Enhancement Effect of Local Anesthetic Action of Lidocaine in Inferior Alveolar Nerve Block: A Randomized Crossover Study; A Study that Awaits Confirmation in a Larger Trial.
Local anesthesia is essential for pain management in dentistry. The duration of anesthetic action of the addition of 5.0 and 7.5 ppm of dexmedetomidine (DEX) was significantly longer than the addition of adrenaline, and the mean duration of anesthetic action of the addition of 2.5 ppm DEX was also longer than the addition of adrenaline. We hypothesized that it is possible to safely achieve an equal local anesthesia effect as with 1:80,000 adrenaline, without using adrenaline or felypressin, by the addition of <2.5 ppm DEX to the local anesthetic solution. ⋯ DEX at a concentration of 1.0 to 2.0 ppm enhances the local anesthetic action of lidocaine. DEX at 2.0 ppm produces similar enhancement of local anesthesia effect as the addition of 1:80,000 adrenaline.