The Clinical journal of pain
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Review Case Reports
Use of buprenorphine in children with chronic pseudoobstruction syndrome: case series and review of literature.
Abdominal pain is the most challenging symptom in chronic intestinal pseudoobstruction (CIPO) syndrome, because of its severity and the limited availability of suitable opioid formulations, especially in pediatric patients with digestive problems. Most of the children with CIPO cannot tolerate oral formulations. ⋯ CIPO and the unique pharmacological profile of buprenorphine are reviewed briefly.
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To provide a current overview of the diagnostic work-up and management of painful diabetic polyneuropathy (PDPN). ⋯ As efficacy and tolerability of current therapy for PDPN are not ideal, the need for a better approach in management further exists. Novel compounds should be developed for the treatment of PDPN.
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Randomized Controlled Trial
The pain quality response profile of pregabalin in the treatment of neuropathic pain.
To identify and describe the response profile of pregabalin on the qualities of pain associated with peripheral neuropathy. ⋯ Pregabalin had a greater effect on PQAS-assessed paroxysmal pain than on surface or deep pain in patients with peripheral neuropathy. The findings corroborate previous research demonstrating differential effects of analgesic drugs across pain qualities, further emphasizing the need to assess individual pain qualities in addition to overall pain intensity.
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Previous research suggests that children with autism spectrum disorders (ASD) are at a higher risk for painful experiences, but there is limited research examining pain in children with ASD. ⋯ This is the first study to successfully obtain self-report of pain from youth with ASD. Implications for the understanding of pain and pain assessment in high-functioning youth with ASD are discussed.
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Randomized Controlled Trial Clinical Trial
Interaction of fentanyl and buprenorphine in an experimental model of pain and central sensitization in human volunteers.
: There is controversy about combining opioids with different receptor affinities. We assessed the analgesic and antihyperalgesic effects of the μ-agonist fentanyl and the partial μ-agonist/κ-antagonist buprenorphine in a human pain model, when given alone or in combination. ⋯ : For the doses administered in this study, buprenorphine and fentanyl showed an additive interaction.