The Canadian journal of cardiology
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Randomized Controlled Trial Comparative Study
Effects of levosimendan versus dobutamine on left atrial function in decompensated heart failure.
Although the effects of levosimendan on the left ventricle (LV) have been studied, its effect on left atrial (LA) function is poorly understood, despite its key role in optimizing LV function. ⋯ In patients with DHF, levosimendan and dobutamine both improve LV systolic function. However, levosimendan also improves LV diastolic function and LA performance in parallel with a greater improvement in neurohormonal activation compared with dobutamine.