Pediatric pulmonology
-
Intralobar pulmonary sequestration has generally been considered a congenital malformation in which an accessory lung bud develops, is enveloped by normal lung, and retains its systemic arterial supply. Also usually included in the "sequestration spectrum" are aberrant arteries to normal lung with either normal or anomalous venous connection. We reviewed all surgical pathology specimens and autopsies performed at Texas Children's Hospital from 1955 through 1984. ⋯ Nine were cases of structurally normal lung with an aberrant systemic artery, and five were cystic adenomatoid malformations with a systemic artery. In one older child some features of intralobar sequestration were present, but a major bronchial connection was retained. We propose that most intralobar sequestrations represent either cystic adenomatoid malformations that clinically are unrecognized until they become secondarily infected or developmentally normal lung supplied by a systemic artery.
-
Pediatric pulmonology · May 1986
Trapped gas and airflow limitation in children with cystic fibrosis and asthma.
Trapped gas (TG) has been shown to be present in cystic fibrosis (CF) and asthma, but its relationship with airflow limitation (AL) has not been explored. TG was defined as the difference between the functional residual capacity measured by body plethysmography [FRC(BP)] and that measured by helium dilution [FRC(He)] expressed as a percentage of total lung capacity (TLC). We studied 21 children with CF and 15 with asthma who had a similar degree of AL and hyperinflation, however the children with CF had greater amounts of TG compared with asthma [15% +/- 2 (mean +/- 1 SE) vs 8 +/- 2, P less than 0.05]. ⋯ In asthma, TG did not correlate with the FEF25-75, ME, RV/TLC, Vmax25, or Vmax50. Furthermore, TG was frequently found in patients with asthma with moderate AL while it was often absent in patients with severe AL. For both CF and asthma, neither the severity of AL nor the magnitude of the TG could be predicted from the increase in Vmax50 with helium (delta V50).(ABSTRACT TRUNCATED AT 250 WORDS)