Pediatric pulmonology
-
Pediatric pulmonology · Jun 2009
Multicenter StudyIL1B polymorphisms modulate cystic fibrosis lung disease.
Variability in pulmonary disease severity is found in patients with cystic fibrosis (CF) who have identical mutations in the CF transmembrane conductance regulator (CFTR) gene. We hypothesized that one factor accounting for heterogeneity in pulmonary disease severity is variation in the family of genes affecting the biology of interleukin-1 (IL-1), which impacts acquisition and maintenance of Pseudomonas aeruginosa infection in animal models of chronic infection. ⋯ Our findings suggest that IL1beta is a clinically relevant modulator of CF lung disease.