Pediatric pulmonology
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Pediatric pulmonology · Feb 2011
Randomized Controlled Trial Multicenter StudyRandomized trial of biofilm testing to select antibiotics for cystic fibrosis airway infection.
In cystic fibrosis (CF), conventional antibiotic susceptibility results correlate poorly with clinical outcomes. We hypothesized that biofilm testing would more accurately reflect the susceptibilities of bacteria infecting CF airways. ⋯ In this pilot study, antibiotic regimens based on biofilm testing did not differ significantly from regimens based on conventional testing in terms of microbiological and clinical responses. The predictive value of biofilm testing may nonetheless warrant evaluation in an adequately powered clinical trial in younger CF patients or those experiencing acute pulmonary exacerbation.