The Journal of international medical research
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Randomized Controlled Trial Multicenter Study
Prolonged-release oxycodone/naloxone in postoperative pain management: from a randomized clinical trial to usual clinical practice.
These studies evaluated the feasibility of using oral prolonged-release oxycodone/naloxone (OXN PR) for the management of acute postoperative pain. ⋯ The analgesic efficacies of OXN PR and OXY PR were similar in postoperative pain settings. OXN PR reduced the degree of restriction in relation to patients carrying out physiotherapy compared with other opioids, and improved bowel and bladder function.
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Randomized Controlled Trial
Target-controlled infusion of remifentanil for laryngeal mask airway insertion during sevoflurane induction in adults.
This randomized, double-blind study investigated the suitable target effect-site concentration of remifentanil for laryngeal mask airway (LMA) insertion during inhalation induction with sevoflurane. ⋯ Compared with 1 ng/ml remifentanil or normal saline, target-controlled infusion of 2 ng/ml remifentanil significantly improved the LMA insertion conditions during sevoflurane inhalational induction, although apnoeic episodes were more frequently observed.
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Randomized Controlled Trial Multicenter Study Comparative Study
Efficacy and tolerability of celecoxib versus naproxen in patients with osteoarthritis of the knee: a randomized, double-blind, double-dummy trial.
To assess the efficacy and tolerability of celecoxib versus naproxen in patients with osteoarthritis (OA) of the knee. ⋯ Over the 6month study period, celecoxib provided similar improvements in OA symptoms to naproxen. In addition, celecoxib provided better upper gastrointestinal tolerability than naproxen.
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Randomized Controlled Trial
Perioperative assessment of terlipressin infusion during living donor liver transplantation.
To investigate the safety and efficacy of infusion of terlipressin during living donor liver transplantation (LDLT). ⋯ Terlipressin infusion improved low SVRI and PVRI during LDLT and may have contributed to better renal function and shorter ICU stays.
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Randomized Controlled Trial Comparative Study
Comparison of preincisional and postincisional parecoxib administration on postoperative pain control and cytokine response after total hip replacement.
To investigate whether preincisional parecoxib administration can reduce postoperative pain and modulate the inflammatory cytokine response to a greater extent than preincisional parecoxib administration in total hip replacement patients. ⋯ Preincisional parecoxib administration reduced postoperative pain and morphine consumption compared with postincisional administration, and attenuated IL-6 and IL-8 production 24 h after hip replacement surgery.