The Journal of international medical research
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Randomized Controlled Trial Comparative Study Clinical Trial
Bioavailability of paracetamol, phenylephrine hydrochloride and guaifenesin in a fixed-combination syrup versus an oral reference product.
The primary objective of this study was to compare the bioavailability of paracetamol, phenylephrine hydrochloride and guaifenesin in a new oral syrup with an established oral reference product. The secondary objective was to compare the safety of the new syrup and the reference product. ⋯ The syrup did not reach bioequivalence with the reference product, as bioequivalence could not be shown for phenylephrine hydrochloride. This may be due to differences in the excipients between the two products. Both the syrup and the reference product had a good safety profile and were well tolerated.
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Randomized Controlled Trial Clinical Trial
Efficacy of intraperitoneal and intravenous lidocaine on pain relief after laparoscopic cholecystectomy.
This randomized, double-blind, placebo-controlled trial evaluated intraperitoneal (IP) lidocaine administration and intravenous (IV) lidocaine infusion for postoperative pain control after laparoscopic cholecystectomy (LC). ⋯ The IP administration of lidocaine and IV lidocaine infusion significantly reduced postoperative pain and opioid consumption in LC patients, compared with control infusions. For convenience, IV lidocaine could be used for pain reduction following LC; IP administration places additional burden on the surgeon.
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Randomized Controlled Trial Clinical Trial
EMLA(R) cream: a pain-relieving strategy for childhood vaccination.
To evaluate the effectiveness of topical eutectic mixture of local anaesthetics (EMLA®) cream in reducing the pain associated with vaccination injections. ⋯ Application of EMLA® cream can be effectively incorporated as a routine pain-relieving intervention within routine vaccination appointments.
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Randomized Controlled Trial Comparative Study
Intrathecal bupivacaine or levobupivacaine: which should be used for elderly patients?
To compare two intrathecal anaesthetics, bupivacaine and levobupivacaine, for their effects on motor and sensory blockade and haemodynamics in patients aged ≥ 65 years undergoing transurethral resection of the prostate (TUR-P) or transurethral resection of the urinary bladder (TUR-M). ⋯ These current findings suggest that levobupivacaine can be used as a substitute for bupivacaine for spinal anaesthesia in elderly patients ≥ 65 years of age undergoing elective TUR-P or TUR-M operations.
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Randomized Controlled Trial
Influence of goal-directed therapy with balanced crystalloid-colloid or unbalanced crystalloid solution on base excess.
To investigate changes in standard base excess (SBE) when administering two different infusion regimens for elective hip replacement within a goal-directed haemodynamic algorithm. ⋯ SBE decreased in the unbalanced group without influence on fluid requirements and haemodynamic stability.