Journal of cataract and refractive surgery
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J Cataract Refract Surg · Nov 1997
Randomized Controlled Trial Comparative Study Clinical TrialTopical anesthesia with pH-adjusted versus standard lidocaine 4% for clear corneal cataract surgery.
To evaluate and compare the efficacy of a sodium-bicarbonate-adjusted preparation of lidocaine 4% (pH = 7.2) and standard lidocaine (pH = 5.2) for topical anesthesia in clear corneal cataract surgery. ⋯ In this study, pH-adjusted lidocaine 4% was a safe, effective topical anesthetic for clear corneal surgery and had minimal local and systemic toxicity. Administration of pH-adjusted lidocaine 4% resulted in significantly higher aqueous humor lidocaine concentrations than administration of standard lidocaine 4%.
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J Cataract Refract Surg · Jun 1997
Randomized Controlled Trial Comparative Study Clinical TrialSedation with ketamine during cataract surgery.
To evaluate the cardiovascular and ocular effects of a low-dose sedation-analgesia regimen in cataract surgery. ⋯ In a regimen with other drugs, ketamine did not influence IOP and enabled comfortable completion of anesthesia and surgery.
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J Cataract Refract Surg · Jun 1996
Randomized Controlled Trial Clinical TrialEfficacy and safety of topical diclofenac in reducing ocular pain after excimer photorefractive keratectomy.
To evaluate the efficacy and safety of diclofenac sodium 0.1% ophthalmic solution in patients having myopic photorefractive keratectomy (PRK). ⋯ Topical diclofenac significantly reduced the ocular pain and discomfort immediately after excimer PRK without any clinically significant complications or adverse effects.
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J Cataract Refract Surg · Jan 1996
Randomized Controlled Trial Comparative Study Clinical TrialComparison of diclofenac sodium and flurbiprofen for inhibition of surgically induced miosis.
To compare the efficacy of two topical nonsteroidal anti-inflammatory drugs, diclofenac sodium and flurbiprofen, commonly used prior to cataract surgery to inhibit surgically induced miosis. ⋯ Diclofenac sodium and flurbiprofen were equally effective in maintaining intraoperative mydriasis during cataract surgery.
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J Cataract Refract Surg · Mar 1995
Randomized Controlled Trial Comparative Study Clinical TrialRelative effectiveness of topical ketorolac and topical diclofenac on discomfort after radial keratotomy.
Two prospective, randomized, double-masked studies were conducted evaluating the analgesic effect of topical eyedrops after radial keratotomy (RK). One study of 117 consecutive initial RK procedures compared topical ketorolac (Acular) with topical diclofenac (Voltaren), and another study of 23 consecutive initial RK procedures compared topical ketorolac with a control medication (HypoTears). ⋯ The onset of analgesic effect of these topical nonsteroidal anti-inflammatory drugs is longer than one hour. The analgesic effect of oral acetaminophen #3 significantly augments that of topical diclofenac drops for those experiencing any discomfort by six hours after surgery.