Journal of cataract and refractive surgery
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J Cataract Refract Surg · Oct 2014
ReviewEfficacy and safety of pain relief medications after photorefractive keratectomy: review of prospective randomized trials.
The objective of this review was to provide a comprehensive overview and comparison of results from all prospective randomized trials published to date of medications used to treat pain after photorefrative keratectomy (PRK). A PubMed database search revealed 23 prospective and randomized studies. They included the following classes of medications: nonsteroidal antiimflammatory drugs (NSAIDs), anesthetics, opiates, acetaminophen, gabapentin, and pregabalin. The studies found that although the efficacy of drugs tended to be similar, tetracaine 1% and nepafenac 0.1% tended to have the most analgesic effect. Delayed corneal reepithelialization was a common side effect of both topical anesthetics and topical NSAIDs. Tetracaine 1% resulted in the most significant delay in reepithelialization when tested against placebo control compared with other topical medications tested against placebo. Concomitant use of topical NSAIDs and topical anesthetics, especially tetracaine, may have to be avoided to minimize the risk for delayed corneal healing. ⋯ Neither author has a financial or proprietary interest in any material or method mentioned.
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Patient-reported outcome is an important part of the evaluation of a surgical procedure. Numerous questionnaires for patient's self-assessed activity limitation because of cataract have been published. ⋯ This review evaluates the psychometric properties of patient questionnaires that have been published since 1992. The evaluation includes questionnaires constructed according to classical test theory and item-response theory.