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Clinical endocrinology
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Clinical endocrinology · Jan 1995
Randomized Controlled Trial Clinical TrialReplacement treatment with biosynthetic human growth hormone in growth hormone-deficient hypopituitary adults.
The physiological role of growth hormone in adult life has recently attracted increased interest. We have studied the clinical effects and the effects on body composition of prolonged replacement with biosynthetic human GH in a large number of hypopituitary adults. ⋯ Growth hormone replacement therapy in adults for 6 months increased lean body mass, total body water and exercise tolerance, and decreased body fat. Growth hormone replacement for longer than 6 months maintains the advantageous effects seen in shorter-term studies and may have additional effects on body fat distribution, muscle strength and psychological well-being.