Journal of general internal medicine
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Randomized Controlled Trial Comparative Study
Mood, side-effects and smoking outcomes among persons with and without probable lifetime depression taking varenicline.
Varenicline may be associated with greater mood disturbance and side-effects among smokers with psychiatric history, but empirical evidence is limited. Differential treatment effectiveness by psychiatric history may also exist. ⋯ While some group differences were noted, DH+ smokers did not report qualitatively worse neuropsychiatric symptoms, more new/worsening mood disturbance, or differential abstinence rates compared to DH- smokers.