Journal of pain and symptom management
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J Pain Symptom Manage · Dec 2021
Randomized Controlled TrialMirtazapine in cancer-associated anorexia and cachexia: A double-blind placebo-controlled randomized trial.
Few pharmacological interventions are available for cancer-associated anorexia and cachexia. Mirtazapine has been suggested for use in cancer-associated anorexia and cachexia. ⋯ Mirtazapine 15mg at night for 28 days is no better than placebo in improving the appetite of incurable solid tumor patients with cancer-associated anorexia and cachexia.
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J Pain Symptom Manage · Nov 2021
Randomized Controlled TrialIncreasing Readiness for Early Integrated Palliative Oncology Care: Development and Initial Evaluation of the EMPOWER 2 Intervention.
Early integrated palliative care improves quality of life, but palliative care programs are underutilized. Psychoeducational interventions explaining palliative care may increase patients' readiness for palliative care. ⋯ This formative research outlines the development of a psychoeducational intervention about palliative care. The intervention is acceptable, feasible, and demonstrated promising pilot test results. This study will guide clinical teams in improving patients' readiness for palliative care and inform the forthcoming EMPOWER 3 randomized clinical trial.
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J Pain Symptom Manage · Oct 2021
Randomized Controlled TrialUnderstanding the Role of Knowledge in Advance Care Planning Engagement.
Advance care planning remains underutilized. A better understanding of the role of education in promoting engagement is needed. ⋯ Knowledge deficits regarding advance care planning are common and associated with the same sociodemographic factors linked to other healthcare disparities. While improving knowledge is an important component of intervention, it is unlikely sufficient in and of itself to increase engagement.
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J Pain Symptom Manage · Oct 2021
Randomized Controlled TrialTRAINING STAFF IN LONG-TERM CARE FACILITIES - EFFECTS ON RESIDENTS' SYMPTOMS, PSYCHOLOGICAL WELL-BEING, AND PROXY SATISFACTION.
Long-term care facility (LTCF) residents have unmet needs in end-of-life and symptom care. ⋯ Our rigorous randomized controlled trial on palliative care training intervention demonstrated mild effects on residents' symptoms and no robust effects on psychological well-being or on proxies' satisfaction with care.
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J Pain Symptom Manage · Sep 2021
Randomized Controlled TrialEffects of an indomethacin oral spray on pain due to oral mucositis in cancer patients treated with radiotherapy and chemotherapy: A double-blind, randomized, placebo-controlled trial (JORTC-PAL04).
Oral mucositis (OM) pain due to anticancer chemo- and radiotherapy has a very negative impact on patient quality of life. However, no high-quality studies have been performed regarding the analgesic efficacy of indomethacin (IM) oral spray for OM pain. ⋯ IM oral spray alleviated short-term OM pain due to anticancer chemo- and radiotherapy, and may reduce the difficulty in eating meals.