Journal of pain and symptom management
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J Pain Symptom Manage · Jun 2021
Randomized Controlled TrialTherapeutic Ultrasound for Chemotherapy-related Pain and Sensory Disturbance in the Hands and Feet in Patients with Colorectal Cancer: A Pilot Randomized Controlled Trial.
This proof-of-concept trial was undertaken as a first step in exploring the clinical benefit of therapeutic ultrasound for pain and sensory disturbance in patients with colorectal cancer. ⋯ The findings of this proof-of-concept study support the feasibility of the therapeutic ultrasound in addition to standard care as an intervention for colorectal cancer patients with oxaliplatin-related pain and sensory disturbance in the hands and feet. The findings warrant a large-scale placebo-controlled trial.
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J Pain Symptom Manage · Jun 2021
Randomized Controlled TrialYoga Practice Predicts Improvements in Day-to-Day Pain in Women With Metastatic Breast Cancer.
Women with metastatic breast cancer (MBC) experience a significant symptom burden, including cancer pain. Yoga is a mind-body discipline that has shown promise for alleviating cancer pain, but few studies have included patients with metastatic disease or examined the acute effects of yoga practice. ⋯ Findings suggest that yoga practice (meditation practice in particular) is associated with acute improvements in cancer pain, and that yoga interventions may be more impactful if tested in a sample of patients with advanced cancer in which pain is relatively elevated.
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J Pain Symptom Manage · Jun 2021
Randomized Controlled TrialFeasibility Trial of Cognitive Behavioral Therapy for Fatigue in Hemodialysis (BReF Intervention).
Fatigue affects at least half of patients who are on hemodialysis (HD) with considerable repercussions on their functioning, quality of life, and clinical outcomes. ⋯ There was promising evidence in support of the need and benefits of a cognitive behavioral therapy-based intervention for fatigue in HD. However, uptake was low, possibly as a result of an already high treatment burden in this setting. Considerations on the context of delivery are necessary before pursuing a definitive trial.
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J Pain Symptom Manage · May 2021
Randomized Controlled TrialIntranasal Fentanyl versus Placebo for Treatment of Episodic Breathlessness in Hospice Patients with Advanced Non-malignant Diseases.
Episodic breathlessness is a distressing and difficult to treat symptom because of its short duration. Fast actioned intranasal fentanyl (INF) is potentially more suitable than oral opioids. ⋯ We found no difference between INF and placebo in relieving episodic breathlessness in nonmalignant conditions. INF was well tolerated, and the study design proved to be feasible in hospice patients with advanced diseases. Future study using higher concentration of fentanyl solution may be warranted.
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J Pain Symptom Manage · Mar 2021
Randomized Controlled TrialStable symptom clusters and evolving symptom networks in relation to chemotherapy cycles.
The existence of stable symptom clusters with variations or changes in cluster membership and the merging of symptom clusters over time urge us to investigate how symptom relationships change over time. ⋯ Stable symptom clusters and evolving networks were identified. The most central symptom was fatigue; however, the paucity of studies that investigated symptom networks and central symptoms calls for further investigations on these phenomena. Identification of central symptoms and underlying mechanisms will guide efficient symptom management. Future studies will need to focus on developing comprehensive interventions for managing symptom clusters or targeting central symptoms.