Journal of pain and symptom management
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J Pain Symptom Manage · Oct 2021
Randomized Controlled TrialTRAINING STAFF IN LONG-TERM CARE FACILITIES - EFFECTS ON RESIDENTS' SYMPTOMS, PSYCHOLOGICAL WELL-BEING, AND PROXY SATISFACTION.
Long-term care facility (LTCF) residents have unmet needs in end-of-life and symptom care. ⋯ Our rigorous randomized controlled trial on palliative care training intervention demonstrated mild effects on residents' symptoms and no robust effects on psychological well-being or on proxies' satisfaction with care.
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J Pain Symptom Manage · Sep 2021
Randomized Controlled TrialEffects of an indomethacin oral spray on pain due to oral mucositis in cancer patients treated with radiotherapy and chemotherapy: A double-blind, randomized, placebo-controlled trial (JORTC-PAL04).
Oral mucositis (OM) pain due to anticancer chemo- and radiotherapy has a very negative impact on patient quality of life. However, no high-quality studies have been performed regarding the analgesic efficacy of indomethacin (IM) oral spray for OM pain. ⋯ IM oral spray alleviated short-term OM pain due to anticancer chemo- and radiotherapy, and may reduce the difficulty in eating meals.
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J Pain Symptom Manage · Aug 2021
Randomized Controlled TrialPredictors of Response to an Evidence-based Behavioral Cancer Pain Management Intervention: An Exploratory Analysis from a Clinical Trial.
Interventions that teach patients cognitive and behavioral strategies for managing cancer pain have demonstrated effectiveness. Systematic reviews of such interventions call for research to inform their implementation in practice, including investigations into which patients are most likely to benefit. ⋯ Our findings elucidate several subgroups of patients who may be especially likely to benefit from PCST, informing both targeted implementation efforts and opportunities to improve delivery for diverse patients.
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J Pain Symptom Manage · Aug 2021
Randomized Controlled TrialFixed-Dose Netupitant and Palonosetron for Chronic Nausea in Cancer Patients: A Double-Blind, Placebo Run-In Pilot Randomized Clinical Trial.
No clinical trials have examined the effect of netupitant/palonosetron (NEPA) on chronic nausea in patients with cancer. ⋯ NEPA and placebo were associated with similar magnitude of within-group improvement in chronic nausea without significant between-group differences (Clinicaltrials.gov NCT03040726).
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J Pain Symptom Manage · Aug 2021
Randomized Controlled TrialPalliative Long-term Abdominal Drains Versus Large Volume Paracentesis in Refractory Ascites due to Cirrhosis (REDUCe Study): Qualitative Outcomes.
Palliative care remains suboptimal in end-stage liver disease (ESLD). ⋯ Patients and nurses expressed acceptability of palliative LTAD in ESLD and preference for this approach in enabling care at home. Proceeding to a definitive trial is feasible.