Journal of pain and symptom management
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J Pain Symptom Manage · Aug 2021
Randomized Controlled TrialFixed-Dose Netupitant and Palonosetron for Chronic Nausea in Cancer Patients: A Double-Blind, Placebo Run-In Pilot Randomized Clinical Trial.
No clinical trials have examined the effect of netupitant/palonosetron (NEPA) on chronic nausea in patients with cancer. ⋯ NEPA and placebo were associated with similar magnitude of within-group improvement in chronic nausea without significant between-group differences (Clinicaltrials.gov NCT03040726).
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J Pain Symptom Manage · Aug 2021
Randomized Controlled TrialPredictors of Response to an Evidence-based Behavioral Cancer Pain Management Intervention: An Exploratory Analysis from a Clinical Trial.
Interventions that teach patients cognitive and behavioral strategies for managing cancer pain have demonstrated effectiveness. Systematic reviews of such interventions call for research to inform their implementation in practice, including investigations into which patients are most likely to benefit. ⋯ Our findings elucidate several subgroups of patients who may be especially likely to benefit from PCST, informing both targeted implementation efforts and opportunities to improve delivery for diverse patients.
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J Pain Symptom Manage · Aug 2021
Randomized Controlled TrialPalliative Long-term Abdominal Drains Versus Large Volume Paracentesis in Refractory Ascites due to Cirrhosis (REDUCe Study): Qualitative Outcomes.
Palliative care remains suboptimal in end-stage liver disease (ESLD). ⋯ Patients and nurses expressed acceptability of palliative LTAD in ESLD and preference for this approach in enabling care at home. Proceeding to a definitive trial is feasible.
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J Pain Symptom Manage · Jun 2021
Randomized Controlled TrialThe Effects of Clinical Music Therapy on Resiliency in Adults Undergoing Infusion: A Randomized, Controlled Trial.
Eighty-seven patients newly diagnosed with lung, breast, or gastrointestinal cancer and undergoing chemotherapy in the infusion suite of a large urban hospital in New York City. ⋯ Our study shows MT's facility to propel resilience in patients newly diagnosed with cancer, particularly when promoting and pairing adaptation toward coping through the expression of perceived negative effects of emotional and physiological symptoms.
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J Pain Symptom Manage · Jun 2021
Randomized Controlled TrialRandomized Trial of Scrambler Therapy for Chemotherapy-Induced Peripheral Neuropathy: Crossover Analysis.
Preliminary trials report that Scrambler Therapy, a form of electroanalgesia, may improve discomfort from chemotherapy-induced peripheral neuropathy (CIPN). ⋯ Similar findings from the initial randomization and crossover phases of this study support further evaluation of the efficacy of Scrambler therapy in alleviating CIPN symptoms. Evaluation in a larger, randomized controlled trial with standardized treatment is warranted.