Journal of gastroenterology and hepatology
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J. Gastroenterol. Hepatol. · Jul 2009
Randomized Controlled Trial Comparative StudyEfficacy of a single 24-hour pre-anesthetic dose of proton pump inhibitors.
The H(2) receptor antagonist roxatidine is routinely used as an oral pre-anesthetic medication in surgical patients at night and 2 h before surgery. In the present study, we have compared the effects of roxatidine, rabeprazole and lansoprazole given singly at night as an alternative to the standard double roxatidine medication. ⋯ Single rabeprazole (but not lansoperazole) medication may be a suitable alternative to standard roxatidine for prophylaxis of acid aspiration pneumonia.