Journal of gastroenterology and hepatology
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J. Gastroenterol. Hepatol. · Mar 2013
Multicenter Study Comparative Study Clinical TrialHistology of symptomatic gastroesophageal reflux disease: is it predictive of response to proton pump inhibitors?
To examine the differences in esophageal histopathology between non-erosive reflux disease (NERD) and reflux esophagitis (RE), and to investigate whether baseline esophageal histopathology can predict the therapeutic response to proton pump inhibitors (PPIs). ⋯ The therapeutic efficacy of PPI can be predicted from the features of biopsied esophageal tissue. Factors predictive of resistance to treatment with PPI are negativity for PGP 9.5 in NERD patients and intraepithelial bleeding in RE patients.
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J. Gastroenterol. Hepatol. · May 2012
Multicenter Study Clinical TrialPredicting the efficacy of proton pump inhibitors in patients with non-erosive reflux disease before therapy using dual-channel 24-h esophageal pH monitoring.
We aimed to determine whether reflux- and symptom-related parameters can predict the efficacy of proton pump inhibitors (PPI) in non-erosive reflux disease (NERD). ⋯ Pre-therapeutic pH monitoring in the lower and mid-esophagus is useful for predicting the efficacy of PPI in NERD patients.
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J. Gastroenterol. Hepatol. · Jan 2012
Multicenter StudyHealth utilities and psychometric quality of life in patients with early- and late-stage hepatitis C virus infection.
Hepatitis C virus (HCV) infection is associated with impairment in health-related quality of life (HRQOL). The purpose of this study was to evaluate HRQOL across the HCV disease spectrum using preference-based (utility) and non-preference-based (psychometric) methods, adjusting for sociodemographic factors and co-morbidity. ⋯ The effect of stage of disease on HRQOL is modest, although viral clearance is associated with higher HRQOL. HCV patients' HRQOL is strongly associated with concomitant illness and sociodemographic factors.
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J. Gastroenterol. Hepatol. · Apr 2009
Multicenter Study Comparative StudyTrends of ulcerative colitis-associated colorectal cancer in Korea: A KASID study.
The number of patients with ulcerative colitis (UC) in Korea has increased. In addition, the number of patients with colorectal cancer (CRC) associated with UC has also increased. Therefore, this population-based nationwide study was conducted to investigate the incidence of CRC in patients with UC in Korea and compare these results to those of studies conducted in other countries. ⋯ The cumulative incidence of UC-associated CRCs in Korea was found to be comparable to that of western countries. The overall occurrence of UC-associated CRC in Korea may be growing, therefore, intensive surveillance colonoscopy and constructive chemoprevention should be encouraged to enable early detection and treatment of UC-associated CRCs in Korea.
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J. Gastroenterol. Hepatol. · Mar 2009
Multicenter StudyDevelopment and evaluation of the quality of life instrument in chronic liver disease patients with minimal hepatic encephalopathy.
The objective was to develop a valid and reliable health-related quality of life (HRQOL) assessment tool to measure the functional and health status of patients with minimal hepatic encephalopathy (mHE). ⋯ The instrument is short, easy to administer and is of good validity and reliability in patients with mHE.