Journal of gastroenterology and hepatology
-
J. Gastroenterol. Hepatol. · Dec 2019
Circulating insulin-like growth factor binding protein-3 and risk of gastrointestinal malignant tumors.
Insulin-like growth factor-1 (IGF1) is a potent mitogen and is inhibited by IGF-binding protein-3 (IGFBP3). High serum IGF1 and low IGFBP3 are associated with increased risk of several carcinomas. Here, we assessed the relationship of these peptides with the risk of gastrointestinal malignancies, in a prospective case-control study nested in the Japan Collaborative Cohort Study. ⋯ Both total and free IGFBP3 may be inversely associated with the incidence of gastrointestinal malignancies.
-
J. Gastroenterol. Hepatol. · Sep 2019
Association of low skeletal muscle mass with advanced liver fibrosis in patients with non-alcoholic fatty liver disease.
Although low skeletal muscle mass (LSMM) is known to increase the risk of non-alcoholic fatty liver disease (NAFLD), limited reports have described the relationship between LSMM and advanced fibrosis. Here, we investigated the association between LSMM and advanced liver fibrosis in NAFLD patients. ⋯ Low skeletal muscle mass is associated with advanced fibrosis in NAFLD patients independent of metabolic risk factors.
-
J. Gastroenterol. Hepatol. · Aug 2019
Meta AnalysisVonoprazan versus proton-pump inhibitors for healing gastroesophageal reflux disease: A systematic review.
Gastroesophageal reflux disease (GERD) is a common disease caused by reflux of gastric contents to the esophagus. Proton-pump inhibitors (PPIs) are recommended as a first-line therapy to treat GERD. Recently, a new potassium-competitive acid blocker, vonoprazan, was launched in Japan. We aimed to evaluate the comparative efficacy of vonoprazan and other PPIs in healing GERD. ⋯ This analysis shows that the GERD healing effect of vonoprazan is higher than that of rabeprazole (20 mg) but not higher than other PPIs. Subgroup analysis indicated that vonoprazan is more effective than most PPIs for patients with severe erosive esophagitis.