Journal of gastroenterology and hepatology
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J. Gastroenterol. Hepatol. · Dec 2019
Circulating insulin-like growth factor binding protein-3 and risk of gastrointestinal malignant tumors.
Insulin-like growth factor-1 (IGF1) is a potent mitogen and is inhibited by IGF-binding protein-3 (IGFBP3). High serum IGF1 and low IGFBP3 are associated with increased risk of several carcinomas. Here, we assessed the relationship of these peptides with the risk of gastrointestinal malignancies, in a prospective case-control study nested in the Japan Collaborative Cohort Study. ⋯ Both total and free IGFBP3 may be inversely associated with the incidence of gastrointestinal malignancies.
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J. Gastroenterol. Hepatol. · Sep 2019
Association of low skeletal muscle mass with advanced liver fibrosis in patients with non-alcoholic fatty liver disease.
Although low skeletal muscle mass (LSMM) is known to increase the risk of non-alcoholic fatty liver disease (NAFLD), limited reports have described the relationship between LSMM and advanced fibrosis. Here, we investigated the association between LSMM and advanced liver fibrosis in NAFLD patients. ⋯ Low skeletal muscle mass is associated with advanced fibrosis in NAFLD patients independent of metabolic risk factors.
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J. Gastroenterol. Hepatol. · Aug 2019
Screening for non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography.
The recommendation in regard to screening for non-alcoholic fatty liver disease (NAFLD) among type 2 diabetes mellitus (T2DM) patients differs in major guidelines. The aim of this paper was to study the prevalence of NALFD and advanced fibrosis among T2DM patients. ⋯ The prevalence of NAFLD and advanced fibrosis based on transient elastography is high among T2DM patients.