Journal of gastroenterology and hepatology
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J. Gastroenterol. Hepatol. · Apr 2003
Randomized Controlled Trial Comparative Study Clinical TrialRandomized controlled trial to compare the dose of adjuvant chemotherapy after curative resection of hepatocellular carcinoma.
Adjuvant locoregional chemotherapy has been shown to be useful to prevent recurrence after curative resection of hepatocellular carcinoma (HCC) in some retrospective studies. Our aim was to compare the dose effect in the prevention of tumor recurrence. ⋯ There is no significant difference in the survival rates between the two groups. Adjuvant chemotherapy may not be useful.
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J. Gastroenterol. Hepatol. · Mar 1991
Randomized Controlled Trial Comparative Study Clinical TrialA double-blind study of misoprostol (SC-29333) in the healing of duodenal ulcer.
In a double-blind randomized placebo controlled trial, 50 patients with endoscopically confirmed duodenal ulcer were treated with either misoprostol 200 micrograms or placebo in q.i.d. doses for 4-8 weeks. Of 25 patients in the placebo group, four defaulted and two were withdrawn due to worsening of symptoms. Of 25 misoprostol-treated cases, 17 cases (68%) and 21 cases (84%) healed at 4 and 8 weeks respectively, compared with three (14%) and five (24%) of the 21 placebo-treated cases (P less than 0.001). Except for diarrhoea in 2 patients in each group and itching in one with misoprostol, no serious side effects were noted.