Current medical research and opinion
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
A randomized controlled study comparing rofecoxib, diclofenac sodium, and placebo in post-bunionectomy pain.
The relative efficacy of rofecoxib, diclofenac sodium, and placebo were compared in the treatment of acute pain after bunionectomy surgery. ⋯ Rofecoxib 50 mg was significantly more effective than placebo on all measures of treatment of post-bunionectomy pain. Rofecoxib 50 mg was significantly more effective than diclofenac sodium 100 mg based on Day 1 endpoints of total pain relief, onset time, and duration of response. All study medications were generally well tolerated.