Current medical research and opinion
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Randomized Controlled Trial
Association of baseline disease and patient characteristics with response to etoricoxib and indomethacin for acute gout.
Disease history and clinical features can influence treatment response in patients with acute gout. The purpose of this pooled subgroup analysis was to assess the association of baseline disease and patient characteristics with response to treatment in acute gout using data from two identical studies. ⋯ This pooled subgroup analysis demonstrated significantly greater response of acute gout to either etoricoxib or indomethacin among those with monoarticular disease, severe/extreme baseline pain, and non-use of colchicine and/or allopurinol. These results should be interpreted in the context of a pooled subgroup analysis with a limited sample size, and with the understanding that associations identified in such analyses do not define causation. Despite limitations, the results provide insights into the types of patients more likely to respond better to anti-inflammatory medication, and reiterate the importance of earlier effective control of the disease.
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Randomized Controlled Trial
Pain relief and pain-related sleep disturbance with extended-release tramadol in patients with osteoarthritis.
This analysis evaluated changes in pain and pain-related sleep disturbance with extended-release tramadol (tramadol ER) in patients with moderate, chronic osteoarthritis pain, and the influence of pain reduction on pain-related sleep disturbance. ⋯ In patients with chronic osteoarthritis pain, pain reduction is associated with decreased pain-related sleep disturbance.